Ulixertinib hydrochloride New
Data Sheet
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| CAS No. | 1956366-10-1 | Cat. No. | BCP30834 |
| Name | Ulixertinib hydrochloride | ||
| Synonyms | Ulixertinib HCl;BVD-523 HCl;BVD 523 HCl;BVD523 HCl;VRT752271 HCl;VRT752271 HCl; VRT 752271 HCl;Ulixertinib HCl salt; | ||
| SMILES | CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)Cl.Cl | ||
| Chemical Name | |||
| Formula | C21H23Cl3N4O2 | M. Wt | 469.79 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. | ||
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