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NF κB

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NF κB

Chemical Structure Cat. No. Product Name CAS No.
WAY-204688 Chemical Structure
 BCP46376 WAY-204688 796854-35-8
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAECT-1 cells).
SP-8356 Chemical Structure
 BCP45208 SP-8356 1454885-45-0
SP-8356 an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor.
N-Acetyl-cysteine Chemical Structure
 BCP45078 N-Acetyl-cysteine 616-91-1
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results. Acetylcysteine was granted FDA approval on 14 September 1963.
B022 Chemical Structure
 BCP45058 B022 1202764-53-1
B022 is a novel inhibitor of NF-kappaB-inducing kinase (NIK), protecting liver from toxin-induced inflammation, oxidative stress, and injury.
Hoipin-1 Chemical Structure
 BCP43940 Hoipin-1 JTP-0819958
HOIPIN-1 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM.
Lipoteichoic acid Chemical Structure
 BCP43680 Lipoteichoic acid 56411-57-5
Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways, also used as adjuvant.
IT-603 Chemical Structure
 BCP43206 IT-603 292168-90-2
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603. IT-603 is a NF-κB family member c-Rel inhibitor with an IC50 of 3 μM in electrophoretic mobility shift assay (EMSA).
UCB-9260 Chemical Structure
 BCP40717 UCB-9260 1515888-53-5
UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer.
NIK SMI1 Chemical Structure
 BCP38023 NIK SMI1 1660114-31-7
NIK SMI1 is a highly selective and potent NF-κB-inducing kinase (NIK) inhibitor.
SEMBL Chemical Structure
 BCP38022 SEMBL 1443448-82-5
SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.
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