Home   >  
Wnt/Stem Cell
  >  
Hedgehog

Classified by application

All Products

Signaling Pathways

Research Areas

Nature products

Antibodies

Peptides

Catalysts

Impurities

Intermediate

Raw Materials

Hedgehog

Chemical Structure Cat. No. Product Name CAS No.
Dynarrestin Chemical Structure
 BCP44170 Dynarrestin 2222768-84-3
Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
Robotnikinin Chemical Structure
 BCP20109 Robotnikinin 1132653-79-2
Robotnikinin is an inhibitor of Shh signaling in a concentration-dependant manner.
Jervine Chemical Structure
 BCP28214 Jervine 469-59-0
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
Saridegib hydrochloride Chemical Structure
 BCP21080 Saridegib hydrochloride 1169829-40-6
Saridegib is an orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity.
JK184 Chemical Structure
 BCP21568 JK184 315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.
TAK-441 Chemical Structure
 BCP20946 TAK-441 1186231-83-3
TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway.
GANT61 Chemical Structure
 BCP08050 GANT61 500579-04-4
GANT 61 is a small molecule inhibitor of Gli1 and Gli2.
SAG Chemical Structure
 BCP14694 SAG 912545-86-9
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).
MK-4101 Chemical Structure
 BCP18385 MK-4101 935273-79-3
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
PF-5274857 Chemical Structure
 BCP06737 PF-5274857 1373615-35-0
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
12下一页共 19 条记录 1 / 2 页 
0086-13720134139