Trastuzumab emtansine New
Size | Price | Stock | Quotation Inquiry |
---|---|---|---|
1.00 mg | Get quote | In-stock | Quotation Inquiry |
5.00 mg | Get quote | In-stock | Quotation Inquiry |
10.00 mg | Get quote | In-stock | Quotation Inquiry |
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS No. | 1018448-65-1 | Cat. No. | BCP30527 |
Name | Trastuzumab emtansine | ||
Synonyms | Ado-trastuzumab emtansine;Kadcyla; trastuzumab-DM1; trastuzumab-MCC-DM1; trastuzumab-MCC-DM1 antibody-drug conjugate; T-DM1; PRO132365; | ||
SMILES | |||
Chemical Name | |||
Formula | M. Wt | 148.5 kg/mol | |
Purity | 98% | Storage | Store at 4-8°C |
Description | Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Check for active clinical trials or closed clinical trials using this agent. |
Recommend Products
More >Tags:Trastuzumab emtansine supplier,Trastuzumab emtansine purchase,Trastuzumab emtansine manufacturer,Trastuzumab emtansine distributor,Trastuzumab emtansine cost,Trastuzumab emtansine buy,Trastuzumab emtansine for sale