ABC-1183 New
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| CAS No. | 1042735-18-1 | Cat. No. | BCP30547 |
| Name | ABC-1183 | ||
| Synonyms | ABC1183; ABC 1183; | ||
| SMILES | CC1=CC=C(C=C1)NC2=NC(=C(S2)C(=O)C3=CC=C(C=C3)C#N)N | ||
| Chemical Name | |||
| Formula | C18H14N4OS | M. Wt | 334.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ABC-1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modulates oncogenic signaling through changes in GSK3, GS and β-catenin phosphorylation and MCL1 expression; suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms without organ or hematological toxicity in vivo. | ||
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