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Plerixafor Chemical Structure

Plerixafor

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02337CAS No. :110078-46-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 110078-46-1 Cat. No. BCP02337
Name Plerixafor
Synonyms JM-3100; JM 3100; JM3100; AMD-3100; AMD 3100; AMD3100;
SMILES
Chemical Name
Formula C28H54N8 M. Wt 502.78
Purity 98% Storage Store at 4-8°C
Description Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4. Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits SDF-1 mediated GTP-binding, SDF-1 mediated calcium flux and SDF-1 stimulated chemotaxis with IC50 of 27 nM, 572 nM and 51 nM, respectively. Plerixafor does not inhibit calcium flux against cells expressing CXCR3, CCR1, CCR2b, CCR4, CCR5 or CCR7 when stimulated with their cognate ligands, nor does Plerixafor inhibit receptor binding of LTB4. Plerixafor does not, on its own, induce a calcium flux in the CCRF–CEM cells, which express multiple GPCRs including CXCR4, CCR4 and CCR7.
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