JNJ40411813

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP23709CAS No. ：1127498-03-6Purity：98%

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CAS No.	1127498-03-6	Cat. No.	BCP23709
Name	JNJ40411813
Synonyms	JNJ-40411813; JNJ 40411813; ADX71149; ADX 71149; ADX-71149;
SMILES	O=C1C(Cl)=C(N2CCC(C3=CC=CC=C3)CC2)C=CN1CCCC
Chemical Name
Formula	C20H25ClN2O	M. Wt	344.88
Purity	98%	Storage	Store at 4-8°C
Description	JNJ-40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ-40411813 acts as a PAM at the cloned mGlu2 receptor: EC50 = 147 ± 42 nmol/L in a [(35)S]GTPγS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50 = 64 ± 29 nmol/L in a Ca(2+) mobilization assay with hmGlu2 G α16 cotransfected HEK293 cells. JNJ-40411813 displaced [(3)H]JNJ-40068782 and [(3)H]JNJ-46281222 (mGlu2 receptor PAMs), while it failed to displace [(3)H]LY341495 (a competitive mGlu2/3 receptor antagonist). JNJ-40411813 is an interesting candidate to explore the therapeutic potential of mGlu2 PAMs, in in vivo rodents experiments as well as in clinical studies.