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Nelarabine Chemical Structure

Nelarabine

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02093CAS No. :121032-29-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 121032-29-9 Cat. No. BCP02093
Name Nelarabine
Synonyms Arranon;506U7;
SMILES
Chemical Name
Formula C11H15N5O5 M. Wt 297.27
Purity 98% Storage Store at 4-8°C
Description The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively.Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells.Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity.
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