Home   >  
Angiogenesis/Protein Tyrosine Kinase
  • Jak/Stat Pathway
  >  
EGFR
  >   WZ4002
WZ4002 Chemical Structure

WZ4002

Cat. No. :BCP02515CAS No. :1213269-23-8Purity:98%
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

  • Information
  • Introduction
  • Quality Control
Synonyms WZ 4002;WZ-4002
CAS Number 1213269-23-8
Purity 98%
M. Wt 494.99
Formula C25H27ClN6O3
Storage Store at 4-8°C
WZ4002 inhibits other EGFR genotypes E746_A750 and E746_A750/T790M with IC50 of 2 and 6 nM. Besides, WZ4002 suppresses widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines and WZ4002 prevents of EGFR phosphorylation in NIH-3T3 cells expressing different EGFR T790M mutant alleles. For WZ4002, kinases that exhibited greater than 95% inhibition relative to the DMSO control at 10 μM are selected for measurement of their dissociation constants. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR compared to WZ3146. WZ4002 is 100-fold less effective at inhibiting phosphorylation of WT EGFR compared to the quinazoline inhibitors. Similarly, WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 and gefitinib.In addition, the phosphorylated EGFR of Src TKI-resistant H1975 cells, as well as HCC8

Tags:WZ4002 supplier,WZ4002 purchase,WZ4002 manufacturer,WZ4002 distributor,WZ4002 cost,WZ4002 buy,WZ4002 for sale

0086-13720134139