CHR-6494
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1333377-65-3 | Cat. No. | BCP06799 |
| Name | CHR-6494 | ||
| Synonyms | CHR6494;CHR 6494; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H16N6 | M. Wt | 292.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity. | ||
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