WEHI-345
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1354825-58-3 | Cat. No. | BCP23889 |
| Name | WEHI-345 | ||
| Synonyms | WEHI345; WEHI 345; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H23N7 | M. Wt | 401.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. Despite only delaying NF-κB activation on NOD stimulation, WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice. | ||
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