Abacavir

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP07728CAS No. ：136470-78-5Purity：98%

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CAS No.	136470-78-5	Cat. No.	BCP07728
Name	Abacavir
Synonyms	Ziagen;
SMILES
Chemical Name
Formula	C14H18N6O	M. Wt	286.34
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: In erythrocytes, abacavir influx was rapid, nonsaturable (rate constant=200 pmol/s/mM/microl cell water), and unaffected by inhibitors of nucleoside or nucleobase transport. in vivo: pharmacokinetic, distribution, and toxicological profiles of 1592U89 were distinct from and improved over those of CBV, probably because CBV itself was not appreciably formed from 1592U89 in cells or animals (<2%). The 5'-triphosphate of CBV was a potent, selective inhibitor of HIV-1 RT, with Ki values for DNA polymerases (alpha, beta, gamma, and epsilon which were 90-, 2,900-, 1,200-, and 1,900-fold greater, respectively, than for RT (Ki, 21 nM). 1592U89 was relatively nontoxic to human bone marrow progenitors erythroid burst-forming unit and granulocyte-macrophage CFU (IC50s, 110 microM) and human leukemic and liver tumor cell lines.