Vps34-PIK-III

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP25171CAS No. ：1383716-40-2Purity：98%

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Chemical Properties&Biological Activity

CAS No.	1383716-40-2	Cat. No.	BCP25171
Name	Vps34-PIK-III
Synonyms	PIK-III; VPS34-IN2; VPS34-IN 2; VPS34-IN-2;
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Chemical Name
Formula	C17H17N	M. Wt	319.36
Purity	98%	Storage	Store at 4-8°C
Description	Vps34-PIK-III is a potent and selective inhibitor of VPS34 with an IC50 of 18 nM.PIK-III, also known as VPS34-IN2, is a VPS34 inhibitor which blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. PIK-III binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kα. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, and leads to the stabilization of autophagy substrates. .

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