PF-06409577 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP32554CAS No. ：1467057-23-3Purity：98%

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CAS No.	1467057-23-3	Cat. No.	BCP32554
Name	PF-06409577
Synonyms	PF06409577; PF 06409577; PF-6409577; PF6409577; PF 6409577;
SMILES	C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O
Chemical Name
Formula	C19H16ClNO3	M. Wt	341.79
Purity	98%	Storage	Store at 4-8°C
Description	PF-06409577 is a potent and selective activator of 5′ adenosine monophosphate-activated protein kinase (AMPK) for the Potential Treatment of diabetic nephropathy. PF-06409577 has AMPK α1β1γ1 Kd=9.0 nM. AMPK α1β1γ1 EC50 = 7.0 nM; AMPK α1β2γ1 EC50 > 40000 nM. PF-06409577 showed efficacy in a preclinical model of diabetic nephropathy. Upon the basis of its potent and selective AMPK activation, low metabolic turnover in human hepatocytes, clean off-target profile, and favorable preclinical in vivo efficacy results, PF-06409577 was profiled in regulatory toxicology studies and was subsequently advanced to clinical trials to assess human pharmacokinetics and safety/ tolerability.