(+/-)-Verapamil hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 152-11-4 | Cat. No. | BCP06465 |
| Name | (+/-)-Verapamil hydrochloride | ||
| Synonyms | Cordilox; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H39ClN2O4 | M. Wt | 491.06 |
| Purity | 99% | Storage | Store at 4-8°C |
| Description | in vitro: In the K562/ADR cellline, addition of verapamil to the culture medium (15 microM concentration) resulted in a 3-fold decrease in Pgp expression after 72 hr exposure. The combination of bortezomib and verapamil synergistically decreased the viability of myeloma cells by inducing cell death. Importantly, bortezomib-mediated activation of major UPR components was enhanced by verapamil. The combination of bortezomib and verapamilresulted in caspase activation followed by poly(ADP-ribose) polymerase cleavage, whereas nuclear factor kappaB (NF-kappaB) activity declined in myeloma cells . in vivo: Pretreatment with cadmium plusverapamil produced significant additive effects on ketamine-induced anesthesia (40.88 +/- 2.98 vs 70.32 +/- 4.64 min). In the acute stage (17 days after infection with maximal parasitemia), verapamil treatment not only decreased the incidence of myocardial disease (fibrosis and inflammation), but also protected myocardial beta-adrenergic adenylate cyclase acti | ||
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