Diethylnorspermine HCl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 156886-85-0 | Cat. No. | BCP19157 |
| Name | Diethylnorspermine HCl | ||
| Synonyms | Diethylnorspermine; BE-333; BENSPM; CI-1006; DE-333; DENSPM; BE333; CI1006; DE333; | ||
| SMILES | CCNCCCNCCCNCCCNCC.Cl.Cl.Cl.Cl | ||
| Chemical Name | |||
| Formula | C13H32N4.4HCl | M. Wt | 390.26 |
| Purity | 97% | Storage | Store at 4-8°C |
| Description | Diethylnorspermine, also known as DENSPM, is a potent inducer of spermidine/spermine N1-acetyltransferase, is able to increase enzyme activity 200-1000 fold. The cell death induced by DENSPM treatment was apoptotic, as evidenced by cleavage of procaspase 3 and induction of caspase-3 activity. The DENSPM-induced polyamine depletion was also caused by the inhibition of ornithine decarboxylase. LA-N-1 cells contained a higher level of the prosurvival protein survivin, which was further increased after DENSPM treatment. | ||
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