Remodelin hydrobromide
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1622921-15-6 | Cat. No. | BCP19055 |
| Name | Remodelin hydrobromide | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C15H15BrN4S | M. Wt | 363.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging. | ||
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