RET Kinase inhibitor 1 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1627856-64-7 | Cat. No. | BCP23560 |
| Name | RET Kinase inhibitor 1 | ||
| Synonyms | GSK3179106; GSK-3179106; GSK 3179106; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H21F4N3O4 | M. Wt | 467.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo. GSK3179106 is being developed by GlaxoSmithKline for the treatment of irritable bowel syndrome. GSK3179106 showed IC50s of 0.4 and 11 nM in the biochemical assay and cellular assay, respectively. GSK3179106 had a clean genotoxic profile with no embedded genotoxicity liabilities. | ||
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