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MAZ51 Chemical Structure

MAZ51

Cat. No. :BCP31595CAS No. :163655-37-6Purity:98%
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Synonyms MAZ-51;MAZ 51
CAS Number 163655-37-6
Purity 98%
M. Wt 314.38
Formula C21H18N2O
Storage Store at 4-8°C
MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.

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