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KHS101 hydrochloride Chemical Structure

KHS101 hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP30178CAS No. :1784282-12-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1784282-12-7 Cat. No. BCP30178
Name KHS101 hydrochloride
Synonyms KHS-101 hydrochloride; KHS 101 hydrochloride; KHS-101 HCl; KHS 101 HCl; KHS101 HCl;
SMILES CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.[H]Cl
Chemical Name
Formula C18H22ClN5S M. Wt 375.92
Purity 98% Storage Store at 4-8°C
Description KHS101 hydrochloride is an inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It acts by selectively inducing neuronal differentiation and apoptotic cell death in breast cancer.KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM); works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression; significantly increases neuronal differentiation in rats in vivo.
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