Tegafur
Data Sheet
For research use only. Not for human use.
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| CAS No. | 17902-23-7 | Cat. No. | BCP22714 |
| Name | Tegafur | ||
| Synonyms | Uftoral; Ftorafur; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C8H9FN2O3 | M. Wt | 200.17 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tegafur is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil. When metabolized, it becomes 5-FU. T egafur-uracil is a formulated therapeutic oral agent consisting of a combination of the 5-fluorouracil (5-FU) congener prodrug tegafur (tetrahydrofuranyl-5-fluorouracil) and uracil (1:4). The high concentration of uracil reversibly inhibits the uracil-reducing enzyme dihydropyrimidine dehydrogenase (DPD), thereby inhibiting first-pass DPD-mediated hepatic metabolism of the uracil analogue 5-FU and permitting administration of 5-FU as the orally bioavailable prodrug tegafur. Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. | ||
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