BDA-366 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1821496-27-8 | Cat. No. | BCP25061 |
| Related Products | 1909226-00-1（BDA-366） 142645-19-0（BDA366） | ||
| Name | BDA-366 | ||
| Synonyms | BDA 366; BDA366; | ||
| SMILES | CCN(CC)C[C@@H](O)CNC1=CC=C(NC[C@@H]2OC2)C3=C1C(C4=C(C3=O)C=CC=C4)=O | ||
| Chemical Name | |||
| Formula | C24H29N3O4 | M. Wt | 423.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BDA-366 is a BCL2-BH4 antagonist. BDA-366 suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without significant cytotoxic effects on normal hematopoietic cells or body weight. Thus, BDA-366 functions as a novel BH4-based BCL2 inhibitor and offers an entirely new tool for MM therapy. | ||
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