Gefitinib hydrochloride
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 184475-55-6 | Cat. No. | BCP05217 |
| Name | Gefitinib hydrochloride | ||
| Synonyms | ZD 1839;ZD-1839;ZD1839; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H24ClFN4O3.HCl | M. Wt | 483.37 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhi | ||
Recommend Products
More >
-
Befotertinib
Cat. No.：BCP49575
No.：1835667-63-4
Product Details -
-
-
Almonertinib mesylate
Cat. No.：BCP48089
No.：2134096-06-1
Product Details -
Lapatinib ditosylate
Cat. No.：BCP47521
No.：388082-77-7
Product Details -
Sunvozertinib
Cat. No.：BCP46584
No.：2370013-12-8
Product Details -
-
Amphiregulin, Human Recombinant
Cat. No.：BCP44759
No.：117147-70-3
Product Details -
Almonertinib hydrochloride
Cat. No.：BCP44623
No.：2134096-03-8
Product Details -
PF-06459988
Cat. No.：BCP44108
No.：1428774-45-1
Product Details -
AZ7550 hydrochloride
Cat. No.：BCP43207
No.：2309762-40-9
Product Details -
-
-
Almonertinib
Cat. No.：BCP38312
No.：1899921-05-1
Product Details -
Epertinib hydrochloride
Cat. No.：BCP37982
No.：2071195-74-7
Product Details -
-
Tyrphostin AG 555
Cat. No.：BCP25507
No.：133550-34-2
Product Details -
Tyrphostin RG 13022
Cat. No.：BCP24139
No.：136831-48-6
Product Details -
-
Tyrphostin AG 835
Cat. No.：BCP24136
No.：133550-37-5
Product Details
Tags:Gefitinib hydrochloride supplier,Gefitinib hydrochloride purchase,Gefitinib hydrochloride manufacturer,Gefitinib hydrochloride distributor,Gefitinib hydrochloride cost,Gefitinib hydrochloride buy,Gefitinib hydrochloride for sale