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PA-824 Chemical Structure

PA-824

Data Sheet For research use only. Not for human use.
Cat. No. :BCP21111CAS No. :187235-37-6Purity:98%
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  • Publications Citing of Biochempartner's PA-824
  • Chemical Properties&Biological Activity
CAS No. 187235-37-6 Cat. No. BCP21111
Name PA-824
Synonyms PA824; PA 824; Pretomanid;
SMILES C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
Chemical Name
Formula C14H12F3N3O5 M. Wt 359.26
Purity 98% Storage Store at 4-8°C
Description PA-824 is an experimental anti-tuberculosis drug and one of two nitroimidazoles in phase II clinical trials to treat tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). The activity of PA-824 against M. tuberculosis was also assessed grown under conditions of oxygen depletion. PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole,
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