EAI045 New Discount
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| CAS No. | 1942114-09-1 | Cat. No. | BCP17698 |
| Name | EAI045 | ||
| Synonyms | EAI-045;EAI 045; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H14FN3O3S | M. Wt | 383.4 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | EAI045 is an allosteric, non-ATP competitive inhibitor of mutant EGFR. In vitro studies proved that EAI045 is active and selective for T790M- harboring EGFR mutants that are in a monomer state. In vivo the combination of EAI045 and cetuximab caused a marked tumor shrinkage in a mouse model carrying the EGFR mutant with L858R/T790M/C797S. Therefore, EAI045 is the first allosteric inhibitor that targets T790M and C797S EGFR mutants but it is effective only in combination with cetuximab. | ||
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