AZ-31
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2088113-98-6 | Cat. No. | BCP29471 |
| Name | AZ-31 | ||
| Synonyms | AZ31;AZ 31; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H28N4O3 | M. Wt | 420.513 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZ-31 is a potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM; displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR; reduces upregulation of p21 and blocks G1 arrest in wild-type but not Cdkn1a(p21CIP/WAF1)-/- mice; showes significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. | ||
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