TRC253 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP39099CAS No. ：2110426-27-0Purity：98%

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CAS No.	2110426-27-0	Cat. No.	BCP39099
Name	TRC253
Synonyms	TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253;
SMILES	C1CC2(C1)C(=O)N(C(=S)N2C3=CN=C(C=C3)OC4CCNCC4)C5=CC(=C(N=C5)C#N)C(F)(F)F
Chemical Name
Formula	C23H21F3N6O2S	M. Wt	502.52
Purity	98%	Storage	Store at 4-8°C
Description	TRC253 is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.