SEN177 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2117405-13-5 | Cat. No. | BCP33954 |
| Name | SEN177 | ||
| Synonyms | SEN 177;SEN-177; | ||
| SMILES | CN1C=NN=C1C2CCN(CC2)C3=C(C=CC=N3)C4=CN=C(C=C4)F | ||
| Chemical Name | |||
| Formula | C18H19FN6 | M. Wt | 338.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model. | ||
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