BDP9066 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP42384CAS No. ：2226507-04-4Purity：98%

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CAS No.	2226507-04-4	Cat. No.	BCP42384
Name	BDP9066
Synonyms	BDP-9066; BDP 9066;
SMILES	C1CCNC2(C1)CCCN(C2)C3=C4C(=CNC4=NC=C3)C5=NC=NC=C5
Chemical Name
Formula	C20H24N6	M. Wt	348.44
Purity	98%	Storage	Store at 4-8°C
Description	BDP9066 is a potent and selective MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM . BDP9066 reduced substrate phosphorylation, leading to morphological changes in cancer cells along with inhibition of their motility and invasive character. In over 750 human cancer cell lines tested, BDP9066 displayed consistent anti-proliferative effects with greatest activity in hematological cancer cells. BDP-9066 prevented radiation-driven increases in motility both in vitro and in a clinically relevant orthotopic xenograft model of GBM. Crucially, treatment with BDP-9066 in combination with RT significantly increased survival in this model and markedly reduced infiltration of the contralateral cerebral hemisphere.