TR-14035 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 232271-19-1 | Cat. No. | BCP30639 |
| Name | TR-14035 | ||
| Synonyms | TR 14035; TR14035;MDK-1191; MDK1191; MDK 1191; SB683698; SB 683698; SB-683698; QJ-2620; | ||
| SMILES | COC1=C(C(=CC=C1)OC)C2=CC=C(C=C2)CC(C(=O)O)NC(=O)C3=C(C=CC=C3Cl)Cl | ||
| Chemical Name | |||
| Formula | C24H21Cl2NO5 | M. Wt | 474.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TR14035 blocked the binding of human alpha(4)beta(7) to an (125)I-MAdCAM-Ig fusion protein with IC(50) values of 0.75 nM. TR14035 blocked binding of human alpha(4)beta(7)-expressing RPMI-8866 cells or murine mesenteric lymph node lymphocytes to MAdCAM-Ig with IC(50) values of 0.1 microM. TR14035 blocked adhesion to HEVs [ED(50) of 0.01-0.1 mpk i.v.]. TR-14035 was taken up by rat and human hepatocytes by an apparently single saturable mechanism with K(m) of 6.7 and 2.1 microM, respectively, and taurocholate and digoxin reduced this uptake. | ||
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