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SG2057 Chemical Structure

SG2057

Data Sheet For research use only. Not for human use.
Cat. No. :BCP46387CAS No. :260417-62-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 260417-62-7 Cat. No. BCP46387
Name SG2057
Synonyms SG-2057; SG 2057;
SMILES COC1=C(C=C2C(=C1)C(=O)N3CC(=C)CC3C=N2)OCCCCCOC4=C(C=C5C(=C4)N=CC6CC(=C)CN6C5=O)OC
Chemical Name
Formula C33H36N4O6 M. Wt 584.66
Purity 98% Storage Store at 4-8°C
Description SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48 h period. Significant antitumor activity was demonstrated in several human tumor xenograft models.
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