Bumetanide
Data Sheet
For research use only. Not for human use.
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| CAS No. | 28395-03-1 | Cat. No. | BCP28485 |
| Name | Bumetanide | ||
| Synonyms | Ro 10-6338; PF 1593；Ro-10-6338; PF1593；Ro10-6338; PF-1593; | ||
| SMILES | CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2 | ||
| Chemical Name | |||
| Formula | C17H20N2O5S | M. Wt | 364.42 |
| Purity | 99% | Storage | Store at 4-8°C |
| Description | Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect. | ||
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