Casopitant New
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| CAS No. | 414910-27-3 | Cat. No. | BCP18249 |
| Name | Casopitant | ||
| Synonyms | GW679769; GW 679769; GW-679769; | ||
| SMILES | CC1=C(C=CC(=C1)F)C2CC(CCN2C(=O)N(C)C(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C(=O)C | ||
| Chemical Name | |||
| Formula | C30H35F7N4O2 | M. Wt | 616.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Casopitant is a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. | ||
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