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Casopitant Chemical Structure

Casopitant

Cat. No. :BCP18249CAS No. :414910-27-3Purity:98%
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Synonyms GW679769; GW 679769; GW-679769
CAS Number 414910-27-3
Purity 98%
M. Wt 616.62
Formula C30H35F7N4O2
Storage Store at 4-8°C
Casopitant is a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.

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