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TAK-220 Hydrochloride Chemical Structure

TAK-220 Hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP37346CAS No. :674782-27-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 674782-27-5 Cat. No. BCP37346
Name TAK-220 Hydrochloride
Synonyms TAK220 Hydrochloride;TAK220 HCl;
SMILES CC1=C(C=C(C=C1)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)C(=O)N)C(=O)C4CCN(CC4)C(=O)C)Cl.Cl
Chemical Name
Formula C31H42Cl2N4O3 M. Wt 589.6
Purity 98% Storage Store at 4-8°C
Description TAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.
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