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Trimethoprim Chemical Structure

Trimethoprim

Data Sheet For research use only. Not for human use.
Cat. No. :BCP12148CAS No. :738-70-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 738-70-5 Cat. No. BCP12148
Name Trimethoprim
Synonyms Trimpex;Proloprim;
SMILES
Chemical Name
Formula C14H18N4O3 M. Wt 290.32
Purity 98% Storage Store at 4-8°C
Description Trimethoprim (TMP), an inhibitor of dihydrofolate reductase, decreases the level of tetrahydrofolate supplying one-carbon units for biosynthesis of nucleotides, proteins, and panthotenate. TMP caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B were most efficiently induced by TMP and coaggregated with the insoluble proteins. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydropteroate synthetase, an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug c
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