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CAY10434 Chemical Structure

CAY10434

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP48083CAS No. ：769917-29-5Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 769917-29-5 Cat. No. BCP48083
Related Products 502656-68-0（CAY10462）
Name CAY10434
Synonyms CAY 10434;CAY-10434;
SMILES CN(C)CCCCCCOC1=CC=C(C=C1)N2C=CN=C2
Chemical Name
Formula C17H25N3O M. Wt 287.4
Purity 98% Storage Store at 4-8°C
Description 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. Alkylaryl imidazoles have been previously shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis. CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 value of 8.8 nM when tested in human renal microsomes. CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.
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