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(+)-MK 801 Maleate Chemical Structure

(+)-MK 801 Maleate

Cat. No. :BCP21811CAS No. :77086-22-7Purity:98%
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Synonyms Dizocilpine maleate;Dizocilpine hydrogen maleate;(+)-MK 801;MK 801
CAS Number 77086-22-7
Purity 98%
M. Wt 337.37
Formula C20H19NO4
Storage Store at 4-8°C
(+)-MK 801 (Maleate) is an uncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it. The drug acts as a potent anti-convulsant and likely has dissociative anesthetic properties, but it is not used clinically for this purpose due to the discovery of brain lesions, called Olney's lesions (see below), in test rats. Dizocilpine is the most frequently used non-competitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.

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