20-HETE

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP11073CAS No. ：79551-86-3Purity：98%

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CAS No.	79551-86-3	Cat. No.	BCP11073
Name	20-HETE
Synonyms	20-hydroxy Arachidonic Acid;20-Hydroxyeicosatetraenoic acid;
SMILES
Chemical Name
Formula	C20H32O3	M. Wt	320.47
Purity	98%	Storage	Store at 4-8°C
Description	20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension. in vitro: Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop. in vivo: In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4]. The transgenic mice had overexpressed hepatic CYP4F2, high hepatic 20-HETE and fasting plasma glucose levels but normal insulin level. T