Linifanib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01726CAS No. ：796967-16-3Purity：99%

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CAS No.	796967-16-3	Cat. No.	BCP01726
Name	Linifanib
Synonyms	ABT-869;AL-39324;ABT 869;ABT869;AL 39324;AL39324;
SMILES
Chemical Name
Formula	C21H18FN5O	M. Wt	375.41
Purity	99%	Storage	Store at 4-8°C
Description	Linifanib shows inhibitory to Kit, PDGFRβ and Flt4 with IC50 of 14 nM, 66 nM and 190 nM in kinases assay. Linifanib also inhibits ligand-induced KDR, PDGFRβ, Kit, and CSF-1R phosphorylation with IC50 of 2 nM, 2 nM, 31 nM and 10 nM at cellular level and this cellular potency could be affected by serum protein. Linifanib suppresses VEGF-stimulated HUAEC proliferation with IC50 of 0.2 nM. While Linifanib has weak activity against tumor cells which are not induced by VEGF or PDGF, except for MV4-11 leukemia cells (with constitutively active form of Flt3) with IC50 of 4 nM. Linifanib could cause a decrease in S and G2-M phases with a corresponding increase in the sub-G0-G1 apoptotic population in MV4-11 cells. Linifanib binds to the ATP-binding site of CSF-1R with Ki of 3 nM. Linifanib (10 nM) exhibits a reduced phosphorylation of Akt at Ser473 and decreased phosphorylation of GSK3βat Ser9 in Ba/F3 FLT3 ITD cell lines.