Retosiban New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 820957-38-8 | Cat. No. | BCP46037 |
| Name | Retosiban | ||
| Synonyms | GSK-221149A; GSK 221149A; GSK221149A;GSK 221149;GSK221149;GSK-221149; | ||
| SMILES | CCC(C)C1C(=O)NC(C(=O)N1C(C2=COC(=N2)C)C(=O)N3CCOCC3)C4CC5=CC=CC=C5C4 | ||
| Chemical Name | |||
| Formula | C27H34N4O5 | M. Wt | 494.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Retosiban is an oral active, potent and selective, sub-nanomolar (Ki = 0.65 nM) oxytocin receptor antagonist with >1400-fold selectivity over the related vasopressin receptors. Retosiban inhibits the procontractile effect of stretch on human myometrium. retosiban prevented stretch-induced stimulation of human myometrial contractility. Retosiban treatment is a potential approach for preventing preterm birth in multiple pregnancy. Retosiban is being developed by GlaxoSmithKline for the treatment of preterm labour. | ||
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