(R)-(-)-Rolipram
Data Sheet
For research use only. Not for human use.
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| CAS No. | 85416-75-7 | Cat. No. | BCP14111 |
| Name | (R)-(-)-Rolipram | ||
| Synonyms | (R)-Rolipram; (-)-Rolipram; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H21NO3 | M. Wt | 275.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In intact eosinophils, (-)-rolipram (EC50 = 0.19 +/- 0.02 microM) was 10-fold more potent than (+)-rolipram (EC50 = 1.87 +/- 0.09 microM) in enhancing isoprenaline (10 microM)-stimulated cyclic AMP accumulation. Rolipram was a relatively weak inhibitor of partially purified pig aortic PDE IV and only slight stereospecificity was exhibited [IC50 (-)-rolipram = 1.47 +/- 0.09 microM; IC50 (+)-rolipram = 2.73 +/- 0.38 microM]. The IC50 of rolipram (racemate) of these two fractions was 492 and 79 nM, respectively. The R-(-)-enantiomer of rolipram inhibited the cAMP-phosphodiesterase activity in the latter fraction 10 times more than did S-(+)-rolipram, and the inhibition of the former fraction was less stereospecific . | ||
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