CX5461dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | CX-54612HCl | Cat. No. | BCP37427 |
| Name | CX5461dihydrochloride | ||
| Synonyms | CX-5461 dihydrochloride;CX-5461 2HCl; | ||
| SMILES | CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1.[2 HCl] | ||
| Chemical Name | |||
| Formula | C27H29Cl2N7O2S | M. Wt | 586.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. | ||
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