Gefapixant New
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| CAS No. | 1015787-98-0 | Cat. No. | BCP26079 |
| Name | Gefapixant | ||
| Synonyms | MK-7264; MK 7264; MK7264; AF-219; AF219; AF 219; RO4926219; RO-4926219; RO 4926219; | ||
| SMILES | CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC | ||
| Chemical Name | |||
| Formula | C14H19N5O4S | M. Wt | 353.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Gefapixant, also known as AF-219 or MK-7264, is a P2X3 receptor antagonist. Gefapixant is currently under clinical trials for chronic cough. It is believed that excessive activation of P2X3 receptors is associated with hyper-sensitization of sensory neurons. Neuronal hyper-sensitization in the airways and lungs, triggered by injury or infection, can cause an exaggerated, persistent and frequent urge to cough, so called chronic cough. P2X3 receptors seem to have a key role in mediation of cough neuronal hypersensitivity. Antagonists of P2X3 receptors such as AF-219 are a promising new group of antitussives. | ||
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