JNJ 31020028
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1094873-14-9 | Cat. No. | BCP14600 |
| Name | JNJ 31020028 | ||
| Synonyms | JNJ 31020028;JNJ31020028; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C34H36FN5O2 | M. Wt | 565.68 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04 +/- 0.13) in functional assays . in vivo: JNJ-31020028 occupied Y(2) receptor binding sites (approximately 90% at 10 mg/kg) after subcutaneous administration in rats [1]. Neither systemic (0, 15, 30, and 40 mg/kg, subcutaneously [s.c.]) nor intracerebroventricular (0.0, 0.3, and 1.0 nmol/rat) administration of JNJ-31020028 affected alcohol-reinforced lever pressing or relapse to alcohol seeking behavior following stress exposure. JNJ-31020028 (15 mg/kg, s.c.) did reverse the anxiogenic effects of withdrawal from a single bolus dose of alcohol on the elevated plus-maze, confirming the anxiolytic-like properties of NPY Y2 antagonism . Chronic administration of JNJ-31020028 induced a decrease in immobility time in the forced swim test in OBX while had no effect in control animals . | ||
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