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Gemcitabine hydrochloride Chemical Structure

Gemcitabine hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP04160CAS No. :122111-03-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 122111-03-9 Cat. No. BCP04160
Name Gemcitabine hydrochloride
Synonyms Gemcitabine HCl; LY188011 hydrochloride;LY 188011 hydrochloride;LY-188011 hydrochloride;
SMILES
Chemical Name
Formula C9H12ClF2N3O4 M. Wt 299.66
Purity 98% Storage Store at 4-8°C
Description Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Treatment of BxPC-3 cells with low dose Gemcitabine for 48 hours results in a dose-dependent increase in NF-κB binding. In contrast, NF-κB DNA binding is decreased in BxPC-3 cells treated with the higher Gemcitabine doses for 48 h; however, 24-h treatment with these higher doses increases NF-κB binding in BxPC-3 cells.
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