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BAY 87-2243 hydrochloride Chemical Structure

BAY 87-2243 hydrochloride

Cat. No. :BCP29477CAS No. :1227158-86-2Purity:98%
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Synonyms BAY87-2243 hydrochloride;BAY 87-2243 HCl
CAS Number 1227158-86-2
Purity 98%
M. Wt 561.994
Formula C26H26F3N7O2.HCl
Storage Store at 4-8°C
BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1α expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50.

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