BAY 87-2243 hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1227158-86-2 | Cat. No. | BCP29477 |
| Name | BAY 87-2243 hydrochloride | ||
| Synonyms | BAY87-2243 hydrochloride;BAY 87-2243 HCl; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C26H26F3N7O2.HCl | M. Wt | 561.994 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1α expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50. | ||
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