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Alirocumab Chemical Structure

Alirocumab

Data Sheet For research use only. Not for human use.
Cat. No. :BCP25199CAS No. :1245916-14-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1245916-14-6 Cat. No. BCP25199
Name Alirocumab
Synonyms REGN 727; REGN-727; REGN727; SAR 236553; SAR236553; SAR-236553;
SMILES
Chemical Name
Formula C6472H9996N1736O2032S42 M. Wt 146000
Purity 98% Storage Store at 4-8°C
Description Alirocumab works by inhibiting the PCSK9 protein. PCSK9 binds to the low-density lipoprotein receptor (LDLR) (which takes cholesterol out of circulation), and that binding leads to the receptor being degraded, and less LDL cholesterol being removed from circulation. Inhibiting PCSK9 prevents the receptor from being degraded, and promotes removal of LDL cholesterol from circulation. After subcutaneous administration of alirocumab, maximal suppression of free PCSK9 occurs within 4 to 8 hours and has an apparent half-life of 17 to 20 days. Inhibition is dose-dependent. The antibody is distributed through the circulation, and it is eliminated at low concentrations by binding to its target, and at higher concentrations through a proteolytic pathway.
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