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(+)-JQ-1 Chemical Structure

(+)-JQ-1

Cat. No. :BCP07004CAS No. :1268524-70-4Purity:98%
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Synonyms (+)-JQ1; (+)-JQ-1; (+)-JQ 1; Bromodomain Inhibitor;JQ-1;JQ1;JQ 1
CAS Number 1268524-70-4
Purity 98%
M. Wt 456.99
Formula C23H25ClN4O2S
Storage Store at 4-8°C
(+)-JQ1 is a potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. JQ1 exhibited strong dose-and time- dependent inhibition of BRDT and could significantly diminish the activ

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