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Tropifexor Chemical Structure

Tropifexor

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20878CAS No. :1383816-29-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1383816-29-2 Cat. No. BCP20878
Name Tropifexor
Synonyms LJN452; LJN-452; LJN 452;
SMILES C1CC1C2=C(C(=NO2)C3=CC=CC=C3OC(F)(F)F)COC4CC5CCC(C4)N5C6=NC7=C(C=C(C=C7S6)C(=O)O)F
Chemical Name
Formula C29H25F4N3O5S M. Wt 603.58
Purity 98% Storage Store at 4-8°C
Description Tropifexor, also known as LJN452, is a farnesoid X receptor agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). Potent in vivo activity was demonstrated in rodent PD models by measuring the induction of FXR target genes in various tissues. Tropifexor has advanced into phase 2 human clinical trials in patients with NASH and PBC.
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