T0901317 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP03658CAS No. ：293754-55-9Purity：98%

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CAS No.	293754-55-9	Cat. No.	BCP03658
Name	T0901317
Synonyms	T-0901317;T 0901317; T-1317; T1317; T 1317; TO-91317; TO 901317; TO 901317; TO-091317; TO 091317; TO091317;
SMILES	OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1
Chemical Name
Formula	C17H12F9NO3S	M. Wt	481.33
Purity	98%	Storage	Store at 4-8°C
Description	T0901317 acts through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. T0901317 upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism.T0901317 displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs), 10-fold more potent than natural FXR ligand chenodeoxycholic acid. T0901317, is also a high-affinity ligand for the xenobiotic receptor pregnane X receptor (PXR). T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity.